a tool for identifying drug-targetable redox-active disulphides

Interferon-inducible GTPase 1

Intramolecular

Cysteine 236 and cysteine 410

A redox-regulated disulphide may form within Interferon-inducible GTPase 1 between cysteines 236 and 410.

Details

Redox score ?

66

PDB code

Structure name

the gtpase domains of the immunity-related irga6 dimerize in a parallel head-to-head fashion

Structure deposition date

2015-11-30

Thiol separation (Å)

6

Half-sphere exposure sum ?

46

Minimum pK_a ?

10

% buried

30

Peptide accession

Residue number A

236

Residue number B

410

Peptide name

Interferon-inducible GTPase 1

Ligandability

Cysteine 236 of Interferon-inducible GTPase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 410 of Interferon-inducible GTPase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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